Assurance Methods for Clinical Trials with a Delayed Treatment
Effect
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Documentation for package ‘DTEAssurance’ version 1.3.0
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| add_recruitment_time | Add recruitment time to a survival dataset |
| apply_design_rule | Apply a design rule to paired replicate output |
| apply_GSD_to_trial | Apply a group-sequential design to one simulated trial |
| assurance_adaptive_shiny_app | Launch the 'shiny' adaptive assurance app |
| assurance_shiny_app | Launch the 'shiny' Assurance app |
| calc_dte_assurance | Calculate Assurance for a Trial with a Delayed Treatment Effect |
| calc_dte_assurance_adaptive | Calculates operating characteristics for a Group Sequential Trial with a Delayed Treatment Effect |
| calibrate_matched_futility_boundary | Calibrate a fixed Z-statistic futility boundary |
| calibrate_PP_threshold | Function to calculate the 'optimal' PP threshold value |
| calibrate_PP_timing | Function to calculate the 'optimal' information fraction to calculate PP |
| cens_data | Censor a survival dataset |
| compute_relative_floors | Relative power floors for kappa selection |
| INTEREST | INTEREST data set |
| make_gsd_design | Build the group-sequential design for a GSD_model |
| make_rpact_design_from_GSD_model | Build the group-sequential design for a GSD_model |
| MCMC_sample | MCMC_sample |
| PP_func | Calculate the predictive probability (PP) given interim data and posterior samples |
| REVEL | REVEL data set |
| run_calibration_grid | Simulate PP values and true trial outcomes for PP-threshold calibration |
| run_paired_scenario | Run paired replicates for one scenario, with checkpointing |
| select_kappa_star | Select the PP futility threshold minimising null expected sample size |
| sim_dte | Simulates survival times for a delayed treatment effect (DTE) scenario, where the treatment group experiences a delayed onset of benefit. Control and treatment groups are generated under exponential or Weibull distributions. |
| single_paired_rep | Simulate one paired replicate for post hoc design evaluation |
| summarize_grid_by_kappa | Summarise calibration output over a grid of PP futility thresholds |
| survival_test | Calculate statistical significance on a survival dataset |
| update_priors | Update prior distributions using interim survival data |
| ZODIAC | ZODIAC data set |